Combination chemotherapy and radiotherapy for Hodgkin's disease in children

✍ Scribed by Gritta E. Ianka; Barbara M. Lau; Rainer J. Haas; Harald P. Lieven; Fritz Lampert

• Publisher: Springer
• Year: 1978
• Tongue: English
• Weight: 349 KB
• Volume: 127
• Category: Article
• ISSN: 0340-6997
• DOI: 10.1007/bf00493545

✦ Synopsis

31 children with Hodgkin's disease were treated at the Children's Hospital, University of Munich, between 1963-1976. Before 1971 the diagnosis of abdominal involvement was based solely on physical findings and radiological studies. Treatment consisted of involved-field radiation; chemotherapy was added in selected cases. Of 15 children treated between 1963-1971, 5 are still in their first remission and 2 in their second remission. Since 1971 exploratory laparotomy and splenectomy have been performed. Radiation therapy was changed from involved- to extended-field therapy and combination chemotherapy was added in all the children. No patient from this group of 16 children relapsed during a median observation time of 24 months (range 12-55 months). The toxicity of the combined treatment does not seem to be prohibitive.