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Colorimetric determination of procainamide in injectable preparations

โœ Scribed by J. E. Whitaker; A. M. Hoyt Jr.

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
210 KB
Volume
73
Category
Article
ISSN
0022-3549

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โœฆ Synopsis

A simple, rapid colorimetric method is described which determines procainamide in commercially available, injectable solutions. It is based on complexing the drug with cupric ion and then measuring the absorption at 380 nm. The reaction is fast and the metal-drug ratio in the complex is 1:1. The pH optimum for maximum reaction is 4.0-4.5 which is maintained by an acetate buffer. Linear standard curves were obtained from 1.52 to 6.06 mg/mL. Analysis of 29 commercial samples resulted in an average of 97.3% of the label claim.

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A new rapid, specific, and convenient colorimetric method for the determination of procaine hydrochloride in pharmaceutical preparations is described. This method is based on measurement of the intensity of the orange-red color developed when procaine hydrochloride is allowed to react with 1,2-napht