Colorectal carcinoma: Analysis of management in two medical eras

✍ Scribed by Homayoun K. Nazarian; Armando E. Giuliano; Jonathan R. Hiatt

• Book ID: 102439760
• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 409 KB
• Volume: 52
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/jso.2930520113

✦ Synopsis

Trends in presentation, diagnosis, management, and outcome were analyzed for 503 patients with colorectal cancer seen at the UCLA Medical Center between 1960 and 1970 (Group A; n = 210) and 1980 and 1985 (Group B; n = 293). Patients in the latter group exhibited a shift in site to the right side of the colon (18% in Group A vs. 31% in Group B; P < .0l), an increase in the number of primary resections without colostomy (38% vs. 61%; P < .Ol), a lower overall complication rate (28% vs. 18%; P = .Ol), and a decline in 30-day mortality (6.2% vs. 2%; P = .01). Although little difference was seen in detection of asymptomatic tumors, earlier lesions were treated in the latter group, accounting for substantially reduced rate of recurrence (69% in Group A vs. 44% in Group B; P < .01). Future management should include an emphasis on earlier detection in order to continue the trend toward enhanced survival.