## Abstract The Hedgehog (Hh) signaling pathway plays an important role in human development. Abnormal activation of this pathway has been observed in several types of human cancers, such as the upper gastroβintestinal tract cancers. However, activation of the Hh pathway in colorectal cancers is co
β¦ LIBER β¦
Colorectal cancer: Mutations in a signalling pathway
β Scribed by Parsons, D. Williams; Wang, Tian-Li; Samuels, Yardena; Bardelli, Alberto; Cummins, Jordan M.; DeLong, Laura; Silliman, Natalie; Ptak, Janine; Szabo, Steve; Willson, James K. V.
- Book ID
- 109810770
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 156 KB
- Volume
- 436
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/436792a
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## Abstract Wnt signaling pathway activation __via__ mutation of genetic components, commonly adenomatous polyposis coli (__APC__), has a major role in colorectal cancer (CRC). Most components have not been assessed for mutation in sporadic CRC. We have analyzed __AXIN2__, __CK1__Ξ±, __DKK1__, __GSK