Lynch syndrome, or hereditary nonpolyposis colon cancer (HNPCC), is an autosomaldominant disease accounting for approximately 1 5 % of all colorectal cancer cases. Due to the lack of pathognomonic morphological or biomolecular markers, HNPCC has traditionally posed unique problems to clinicians and
Colorectal cancer: Molecular genetic studies and their future clinical applications
β Scribed by Fearon, Eric R.
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 642 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0098-1532
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Hereditary nonpolyposis colorectal carcinoma (HNPCC) is the most common hereditary form of colorectal carcinoma (CRC) and may account for 5-10% of the total CRC burden. The discovery of DNA mismatch repair (MMR) genes, inclusive of hMSH2, hMLH1, hPMS2, and hMSH6, has enabled the identification of wh