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Colony-stimulating factor-1 receptor gene polymorphisms and Crohn’s disease

✍ Scribed by Euphemia Leung; Jiwon Hong; Alan G. Fraser; Tony R. Merriman; Prakash Vishnu; Geoffrey W. Krissansen


Publisher
Springer
Year
2006
Tongue
English
Weight
69 KB
Volume
22
Category
Article
ISSN
0179-1958

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The macrophage colony-stimulating factor, CSF-1 (M-CSF), is a homodimeric glycoprotein required for the lineage-specific growth of cells of the mononuclear phagocyte series. Apart from its role in stimulating the proliferation of bone marrowderived precursors of monocytes and macrophages, CSF-1 acts