Colony-stimulating factor-1 in immunity and inflammation

✍ Scribed by Violeta Chitu; E Richard Stanley

• Book ID: 104014452
• Publisher: Elsevier Science
• Year: 2006
• Tongue: English
• Weight: 364 KB
• Volume: 18
• Category: Article
• ISSN: 0952-7915
• DOI: 10.1016/j.coi.2005.11.006

✦ Synopsis

Colony-stimulating factor-1 (CSF-1, also known as macrophage-CSF) is the primary regulator of the survival, proliferation, differentiation and function of mononuclear phagocytes. Studies that involve CSF-1deficient mice demonstrate that there is a variable requirement for CSF-1 in the development of individual mononuclear phagocyte populations. However, these cells uniformly express the CSF-1 receptor, and their morphology, phagocytosis and responsiveness to infectious and non-infectious stimuli is regulated by CSF-1. CSF-1 plays important roles in innate immunity, cancer and inflammatory diseases, including systemic lupus erythematosus, arthritis, atherosclerosis and obesity. In several conditions, activation of macrophages involves a CSF-1 autocrine loop. In addition, secreted and cell-surface isoforms of CSF-1 can have differential effects in inflammation and immunity.