Colon-specific drug delivery using ethylcellulose and chitosan in the coat of compression-coated tablets
β Scribed by Omwancha, Wycliffe; Kouba, Chahinaz; Yelamanchili, Satish; Neau, Steven H.
- Book ID
- 121307415
- Publisher
- Informa plc
- Year
- 2011
- Tongue
- English
- Weight
- 892 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0363-9045
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## Abstract The purpose of the present investigation was to achieve successful delivery specifically to the colon using guar gum as a compression coat over a core tablet of triphala. In this study, guar gum along with hydroxy propyl methyl cellulose (HPMC) was used as a compressionβcoating polymer.
The effect of excipient, drug, and osmotic agent loaded in the inner core tablet on the time-controlled disintegration of compression-coated tablet prepared by direct compression with micronized ethylcellulose was investigated. The excipients [spray-dried lactose, hydroxypropyl methyl cellulose, sod