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Colocalization of Sensors Is Sufficient to Activate the DNA Damage Checkpoint in the Absence of Damage

✍ Scribed by Carla Yaneth Bonilla; Justine Amy Melo; David Paul Toczyski

Book ID
116754545
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
899 KB
Volume
30
Category
Article
ISSN
1097-2765

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## Abstract We have studied the rate of DNA synthesis, cell cycle distribution, formation of γ‐H2AX, and Rad51 nuclear foci and association of Rad51 with the nuclear matrix after treatment of HeLa cells with the interstrand crosslinking agent mitomycin C (MMC) in the presence of the kinase inhibito