Colloidal particle motion as a diagnostic of DNA conformational transitions

✍ Scribed by Philip C. Nelson

• Book ID: 104014131
• Publisher: Elsevier Science
• Year: 2007
• Tongue: English
• Weight: 493 KB
• Volume: 12
• Category: Article
• ISSN: 1359-0294
• DOI: 10.1016/j.cocis.2007.07.015

✦ Synopsis

Tethered particle motion is an experimental technique to monitor conformational changes in single molecules of DNA in real time, by observing the position fluctuations of a micrometer-size particle attached to the DNA. This article reviews some recent work on theoretical problems inherent in the interpretation of TPM experiments, both in equilibrium and dynamical aspects.