Collision-induced dissociations of deprotonated peptides, dipeptides and tripeptides with hydrogen and alkyl α groups. An aid to structure determination
✍ Scribed by Mark Eckersley; John H. Bowie; Roger N. Hayes
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 416 KB
- Volume
- 24
- Category
- Article
- ISSN
- 1076-5174
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✦ Synopsis
The characteristic coUisionLinduced dissociations of (M -HI-ions of dipeptides and tripeptides involve proton transfer to the carboxylate centre as a prelude to fragmentation. Dipeptides show the process + NH,C(R')=C=O (R = H or alkyl) while tripeptides show the analogous processes NH,CH(R')CONHCH(RZ)CONHCH(R3)C0,--+ NH,CH(R')CONHC(RZ)CONHCH(R3)C0,H -+ -NHCH(R3)C0,H + NH,CH(R')CONHC(R2)=C=0 and NH,CH(R')CONHCH(R')-CONHCH(R3)C0,-+ NH,C(R')CONHCH(RZ)CONHCH(R3)C0,H -+ -NHCH(R3)CONHCH(R3)COzH + NH,C(R')=C=O. These fragmentations provide ready identification of the peptide. NH~CH(R')CONHCH(R,)CO, --, NH,C(R~)CONHCH(R~)CO,H -+ -NHCH(R~)CO,H