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Collapse pressures of bilayered biodegradable stents

✍ Scribed by L. P. Tan; Subbu S. Venkatraman; J. F. D. Joso; Freddy Y. C. Boey

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
225 KB
Volume
79B
Category
Article
ISSN
1552-4973

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✦ Synopsis

Abstract

Biodegradable helicoidal stent prototypes made up of layers of poly‐L‐lactic acid (PLLA) and poly(L‐lactic‐co‐glycolic acid) (PLGA) polymers were fabricated by temperature conditioning the stents at different stages of fabrication. The process incorporated elastic memory, or self‐expandability in the stent, which is desirable to minimize stent recoil. The collapse pressures of such stents were studied, with and without in vitro degradation. The effects of thickness and the composition of each layer on the collapse pressure were modeled using the simple series model. Results of the in vitro studies for over 3 months showed that collapse pressure of the stents depended mainly on the degradation and other side‐effects brought about by the degradation of different polymer compositions. Generally, the trend is dominated by the thicker of the two layers that were used to form the stents. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2006

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