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Collagen XI chain misassembly in cartilage of the chondrodysplasia (cho) mouse

✍ Scribed by Russell J. Fernandes; MaryAnn Weis; Melissa A. Scott; Robert E. Seegmiller; David R. Eyre

Book ID
116729634
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
590 KB
Volume
26
Category
Article
ISSN
0945-053X

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## Abstract ## Objective To investigate whether heterozygosity for a loss‐of‐function mutation in the gene encoding the Ξ±1 chain of type XI collagen (__Col11a1__) in mice (chondrodysplasia, __cho__) causes osteoarthritis (OA), and to understand the biochemical and biomechanical effects of this mut