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Collagen, type V, α1 (COL5A1) is regulated by TGF-β in osteoblasts

✍ Scribed by Shireen Kahai; Calvin P.H. Vary; Yuguang Gao; Arun Seth

Book ID
116729223
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
523 KB
Volume
23
Category
Article
ISSN
0945-053X

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## Abstract Connective tissue growth factor (CTGF/CCN2) is induced by transforming growth factor β1 (TGF‐β1) where it acts as a downstream mediator of TGF‐β1 induced matrix production in osteoblasts. We have shown the requirement of Src, Erk, and Smad signaling for CTGF induction by TGF‐β1 in osteo