Collagen induces cytokine production by synovial fluid mononuclear cells in rheumatoid arthritis
β Scribed by Kee-Ching G. Jeng; Ming-Tsung Liu; Joung-Liang Lan; Chi-Huei Wu; David W. Wong; Bruno M.H. Cheung
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 525 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0165-2478
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Objective. To investigate the production of type I1 collagen (CII) antibodies in the synovial fluid (SF) of rheumatoid arthritis (RA) patients, and to examine the HLA dependence of this local production. Methods. The ELISPOT method was used for enumerating anti-CII-reactive cells. Serologic tissue
Adherent rheumatoid synovial cells in culture produce large amounts of prostaglandin E2 (PGE2) and collagenase. When exposed to a monocyte-derived factor, such cells exhibit marked increases in PGE2 and collagenase production. In addition, cellular morphology becomes more stellate. In the presence o