𝔖 Bobbio Scriptorium
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Collagen glomerulopathy and MMP expression in oim mouse kidney

✍ Scribed by Anna M. Roberts; Matthew H. Myles; Andrew Walker; Craig Franklin; Charlotte L. Phillips


Book ID
117983295
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
61 KB
Volume
27
Category
Article
ISSN
0945-053X

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## Background: Oim/oim mice [osteogenesis imperfecta model; homozygous null for the proalpha2(i) collagen gene] synthesize exclusively the homotrimeric type i collagen isotype, alpha1(i)3, and are unable to synthesize the normal heterotrimeric type i collagen isotype, alpha1(i)2alpha2(i). previous

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## Abstract The tight skin 2 (Tsk2) mutation is an ENU induced dominant mutation localized on mouse chromosome 1. While the molecular defect is unknown, Tsk2/+ mice display cutaneous thickening associated with excessive matrix production and are used as a model of scleroderma. The purpose of this s