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Collagen biosynthesis enzymes in serum and hepatic tissue in liver disease : Prolyl hydroxylase

โœ Scribed by EEVA-RIITTA KUUTTI-SAVOLAINEN; JUHA RISTELI; TATU A. MIETTINEN; KARI I. KIVIRIKKO


Book ID
114726022
Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
739 KB
Volume
9
Category
Article
ISSN
0014-2972

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Hepatic fibrosis was induced in rats by repeated i.p. injections of pig serum. The hepatic hydroxyproline content increased to 2.1 times the normal control level at 6 weeks and to 3.2 times at 10 weeks. When P-l894B, an inhibitor of prolyl hydroxylase, was administered, there was a dose-dependent in