Collaborative spirit of histone deacetylases in regulating chromatin structure and gene expression
โ Scribed by Xiang-Jiao Yang; Edward Seto
- Book ID
- 117654952
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 527 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0959-437X
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Acetylation of internal lysine residues of core histone N-terminal domains has been found correlatively associated with transcriptional activation in eukaryotes for more than three decades. Recent discoveries showing that several transcriptional regulators possess intrinsic histone acetyltransferase
## Abstract Both __in vivo__ and __in vitro__ studies indicate a correlation between reduced acetylation of histone core proteins and oligodendrocyte development. The nature of these histone modifications and the mechanisms mediating them remain undefined. To address these issues, we utilized OLโ1