Stimulation of macrophage TNFα productio
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Michelle A. Beidelschies; Honglian Huang; Megan R. McMullen; Matthew V. Smith; A
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Article
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2008
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John Wiley and Sons
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English
⚖ 608 KB
## Abstract Bone loss that causes aseptic loosening of orthopedic implants is initiated by pro‐inflammatory cytokines produced by macrophages in response to implant‐derived wear particles. MAPK and NF‐κB signaling pathways are activated by the particles; however, it is not clear which of the signal