✦ LIBER ✦

Colinearity of novel genes in the class II regions of the MHC in mouse and human

✍ Scribed by Isabel M. Hanson; John Trowsdale

Publisher: Springer-Verlag
Year: 1991
Tongue: English
Weight: 670 KB
Volume: 34
Category: Article
ISSN: 0093-7711
DOI: 10.1007/bf00212306

No coin nor oath required. For personal study only.

✦ Synopsis

To examine the degree of conservation of gene organization in and around the class II regions of the major histocompatibility complexes of mouse and human, we have established the positions of sequences homologous to five human non-class II genes (RING1-5) in mouse, and the positions of sequences homologous to three mouse non-class II genes (KE3-5) in human. The resulting comparative map reveals that the organization of genes in the entire proximal region of the MHCs of mouse and human is remarkably conserved, apart from the H-2K gene pair in mouse, which can be accounted for by a 60 kilobase (kb) insertion. The characterization of the novel human gene RING5 is also presented. This gene, which is widely expressed, maps 85 kb proximal to the DPB2 gene. Partial nucleotide sequencing of a RING5 cDNA clone reveals that it is the human homolog of the mouse KE4 gene.

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