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Colicin M is only bactericidal when provided from outside the cell

✍ Scribed by Robin E. Harkness; Volkmar Braun

Book ID
104703564
Publisher
Springer
Year
1990
Tongue
English
Weight
714 KB
Volume
222
Category
Article
ISSN
1617-4615

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A colicin M derivative containing the li
A colicin M derivative containing the lipoprotein signal sequence is secreted and renders the colicin M target accessible from inside the cells
✍ Tobias Γ–lschlΓ€ger πŸ“‚ Article πŸ“… 1991 πŸ› Springer 🌐 English βš– 963 KB

Colicin M is only released in very low amounts by cells harbouring this plasmid encoded colicin, due to the lack of a release (lysis) protein. A fusion gene (lpp'cma) was constructed which determined two proteins: Lpp'-Cma composed of the signal sequence of the murein lipoprotein (Lpp) and colicin M