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Cold-induced potentiation of α2-adrenergic vasoconstriction in primary raynaud's disease

✍ Scribed by Robert R. Freedman; Marriyam Moten; Peter Migaly; Maureen Mayes

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
541 KB
Volume
36
Category
Article
ISSN
0004-3591

No coin nor oath required. For personal study only.

✦ Synopsis

Objective. To determine the effects of local cooling on a-adrenergic responses in the fingers of patients with idiopathic Raynaud's disease.

Methods. Clonidine HC1 and phenylephrine HCI were administered through a brachial artery catheter while blood flow was measured by plethysmography in cooled and uncooled fingers.

Results. Cooling potentiated a,-adrenergic vasoconstriction in the patients but depressed this response in the controls. Vasoconstrictive responses to phenylephrine were not significantly affected by cooling but were significantly greater in the patients than in the controls.

Conclusion. Cold-induced sensitization of peripheral vascular a,-adrenoceptors may be involved in the mechanism by which cooling triggers the vasospastic attacks of Raynaud's disease.

Raynaud's phenomenon is characterized by digital vasospastic attacks that are generally provoked by exposure to cold. Estimates of the prevalence of the disease range from 4.3% of female respondents to a questionnaire study in the southern United States (1)

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