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Cold-attenuated live influenza vaccines, a risk-benefit assessment

✍ Scribed by Michael Pfleiderer; Johannes Löwer; Reinhard Kurth

Book ID
117430676
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
79 KB
Volume
20
Category
Article
ISSN
0264-410X

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A procedure to attenuate live influenza virus of type A and type B was developed using adaptation of the virus to grow at 25 degrees C (cold adaptation; ca). Through a series of stepwise passages, two stable mutants were obtained and designated as 'Master' strains, one for type A influenza virus (A/