## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
Cold- and Pressure-Induced Dissociation of Protein Aggregates and Amyloid Fibrils
β Scribed by Rajesh Mishra; Roland Winter
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 536 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0044-8249
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## Abstract Macromolecular crowding is expected to have several significant effects on protein aggregation; the major effects will be those due to excluded volume and increased viscosity. In this report we summarize data demonstrating that macromolecular crowding may lead to a dramatic acceleration
The presence of the antiparallel-&pleated sheet conformation in isolated human amyloid protein fibrils has been confirmed by infrared spectroscopy. In most amyloid samples, this conformation was enhanced by acidic solution conditions. Infrared spectroscopy (Amide I and Amide V absorption bands) and