✦ LIBER ✦
Colchicine poisoning: report of a fatal case with body fluid and post-mortem tissue analysis by high-performance liquid chromatography
✍ Scribed by Betty Dehon; Jean-Luc Chagnon; Elisabeth Vinner; Jean Pommery; Daniel Mathieu; Dr Michel Lhermitte
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 46 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0269-3879
No coin nor oath required. For personal study only.
✦ Synopsis
A case involving a suicide by the ingestion of colchicine tablets is presented. Liquid chromatography has been used to measure the drug level in blood and in post-mortem tissues of the patient (a 42-year-old man). Plasma concentration 24 h after ingestion was 4.5 ng/mL. On autopsy, the kidney showed the highest concentration (396 ng/g). High concentrations were also found in the liver (347 ng/g) and heart (334 ng/g). Low concentrations were detected in the lung (58 ng/g), muscle (10 ng/g) and brain (5 ng/g).