✦ LIBER ✦
Colchicine IV. Neuromuscular transmission in isolated frog and rat tissues
✍ Scribed by R. P. Spoor; F. C. Ferguson Jr.
- Publisher
- John Wiley and Sons
- Year
- 1965
- Tongue
- English
- Weight
- 297 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
✦ Synopsis
Colchicine was found to inhibit neuromuscular transmission in the isolated frog sciatic nerve-sartorius muscle preparation but not in the phrenic nerve-diaphragm preparation of the rat. T h e blockade in the frog was readily reversible by washing, was antagonized by neostigmine, but was not antagonized by physostigmine. Dose-response comparisons indicate that in the frog preparation d-tubocurarine is 10,000 times as potent as colchicine; ED60 concentrations were 3 x 10-8 M and 3 x 10-4 M for tubocurarine and colchicine, respectively.