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Colchicine-induced alterations in receptor-stimulated phosphoinositide hydrolysis in the rat hippocampus

✍ Scribed by Pushpa Tandon; G.Jean Harry; Hugh A. Tilson

Book ID
115799955
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
569 KB
Volume
477
Category
Article
ISSN
0006-8993

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Alterations of choline acetyltransferase
Alterations of choline acetyltransferase, phosphoinositide hydrolysis, and cytoskeletal proteins in rat brain in response to colchicine administration
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Colchicine, a microtubule disrupting toxin, was administered intracerebroventricularly to rats, followed by measurements of (i) the activity of choline acetyltransferase, a biochemical marker of cholinergic neurons, (ii) cytoskeletal protein concentrations, including tau, MAP-2, spectrin, and tubuli