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COL1A1 Sp1-binding site polymorphism as a risk factor for genital prolapse

✍ Scribed by Andrea Moura Rodrigues; Manoel João Batista Castello Girão; Ismael Dale Cotrim Guerreiro da Silva; Marair Gracio Ferreira Sartori; Karina de Falco Martins; Rodrigo de Aquino Castro

Publisher: Springer
Year: 2008
Tongue: English
Weight: 114 KB
Volume: 19
Category: Article
ISSN: 0937-3462
DOI: 10.1007/s00192-008-0662-3

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## Abstract ## BACKGROUND. In estrogen biosynthetic pathways, many enzymes are important for metabolism, detoxification, and bioavailability. Polymorphisms in these genes may have an effect on the enzymes' function. For example, higher expression and activation of biosynthetic enzymes and lower ex