Cohabiting t(12;22) and inv(3) primary rearrangements in an acute myelomonocytic leukemia (FAB M4) cell line
✍ Scribed by Roderick A. F. MacLeod; Zhen-Bo Hu; Maren Kaufmann; Hans G. Drexler
- Book ID
- 102655761
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 501 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1045-2257
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✦ Synopsis
We describe the cytogenetic characterization of MUTZ-3. the first continuous cell line to be established from acute myelomonocytic leukemia (FAB M4) cells, exhibiting recurrent chromosomal rearrangements associated with this disease category. MUTZ-3 was established from peripheral blood taken at presentation from a 29-year-old male patient and carries the t( I2;22)(p I 3.2;q I I .2) associated with acute myelomonocytic leukemia (AMMoL), the inv(3)(q2 I .2q26.3) associated with multilineage acute myeloid leukemias (AML), and the inv(7)(p14q35) associated with ataxia telangiectasia (A-T). There was no evidence that the patient was an A-T heterozygote. The breakpoint on chromosome 22 mapped between 5'BCR and D22S39, consistent with the G-banding assignment. Both inversions were translocation-associated and may be further examples of an association previously described in AML FAB M4eo with inv( 16). We suggest that the combination of inv(3)/t(3;3) with t( I2;22) may represent a new, nonrandom association in AML.