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Cogrinding enhances the oral bioavailability of EMD 57033, a poorly water soluble drug, in dogs

✍ Scribed by Markus Vogt; Maria Vertzoni; Klaus Kunath; Christos Reppas; Jennifer B. Dressman


Book ID
116437796
Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
348 KB
Volume
68
Category
Article
ISSN
0939-6411

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✍ Chris G. Thanos; Zhi Liu; Moses Goddard; Joshua Reineke; Nicola Bailey; Matthew πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 237 KB

This article investigates the effect of particle size and the incorporation of a bioadhesive polymer, poly(fumaric-co-sebacic) anhydride p(FA:SA), on the relative bioavailability of dicumarol. A novel method was used to reduce particle size of the drug, and encapsulated formulations were fabricated