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Cognitive synergism of pharmacological analgesia: a new focus for analgesic treatment

✍ Scribed by C.N. Chen, Andrew; F. Dworkin, Samuel


Book ID
123251375
Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
79 KB
Volume
11
Category
Article
ISSN
0304-3959

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The enantiomers of 3-a-tropyl 2-(phenylthio) butyrate (SMT2, 1 ) were prepared by chiral synthesis and tested for analgesic, cognition-enhancing, and ACh-releasing properties. They show enantioselectivity in some of the tests, the eutomer being related in configuration to R-( +)-hyoscyamine.