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✦   LIBER   ✦

Cognitive impulsivity in Parkinson's disease patients: Assessment and pathophysiology

✍ Scribed by Gabriel Robert; Dominique Drapier; Marc Verin; Bruno Millet; Jean-Philippe Azulay; Olivier Blin

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
149 KB
Volume
24
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

Impulsivity may be induced by therapeutic interventions (dopamine replacement therapies and sub‐thalamic nucleus (STN) stimulation) in patients with Parkinson's disease (PD). The present review has two goals. First, to describe the most frequently encountered facets of cognitive impulsivity and to stress the links between cognitive impulsivity and aspects such as reward‐related decision making, risk‐taking, and time‐processing in healthy population. The most widely used related cognitive impulsivity paradigms are presented. Second, to review the results of studies on cognitive impulsivity in healthy volunteers and in patients with PD, the latter support the applicability and clinical relevance of this construct in PD population. Data show that PD treatments may favor impulsivity via different mechanisms. Suggestions on the roles of dopamine and STN in the pathophysiology of cognitive impulsivity are proposed. © 2009 Movement Disorder Society

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