Cognitive impairment in amyotrophic lateral sclerosis and its relation to motor disabilities
β Scribed by Y. Iwasaki; M. Kinoshita; K. Ikeda; K. Takamiya; T. Shiojima
- Book ID
- 114783121
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 296 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0001-6314
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The objective of this study was to examine the contribution of lower motor neuron (LMN) and upper motor neuron (UMN) dysfunction to weakness and impaired motor control in 27 patients with amyotrophic lateral sclerosis (ALS). Isometric strength was measured by dorsiflexor maximum voluntary contractio
Mutations of Cu,Zn superoxide dismutase cause an autosomal dominant form of familial amyotrophic lateral sclerosis. An animal model of the disease has been produced by expressing mutant human SOD1 in transgenic mice (G93A). In order to quantify the dysfunction of the motor unit in transgenic mice, e
Motor conduction velocity is expected to be normal or nearly normal in amyotrophic lateral sclerosis (ALS). Some studies have suggested that pathology may be present in the proximal axons. Indeed, some investigators have shown a decrease in the proximal conduction velocity in ALS by using motor cond