Cognitive, behavioral, and neuroanatomical assessment of two unrelated male children expressingFRAXE
✍ Scribed by Abrams, Michael T.; Doheny, Kimberly F.; Mazzocco, Michele M.M.; Knight, Samantha J.L.; Baumgardner, Thomas L.; Freund, Lisa S.; Davies, Kay E.; Reiss, Allan L.
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 243 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0148-7299
No coin nor oath required. For personal study only.
✦ Synopsis
Standardized cognitive, behavioral, and neuroanatomical data are presented on 2 unrelated boys with the FRAXE (FMR2) GCC expansion mutation. In the context of normal IQ, both boys had a history of developmental delay, including significant problems with communication, attention, and overactivity. Additionally, one child was diagnosed with autistic disorder. Data from these 2 cases are compared to analogous information from previous reports about individuals with the FRAXE or FRAXA (FMR1) mutation. These comparisons support the idea that FRAXE is associated with nonspecific developmental delay and possibly highfunctioning autism.