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Coexistence of reduced function of natural killer cells and osteoclasts in two distinct osteopetrotic mutations in the rat

✍ Scribed by Dr. Steven N. Popoff; Mary E. Jackson; Steven B. Koevary; Sandy C. Marks Jr


Book ID
112118708
Publisher
American Society for Bone and Mineral Research
Year
2009
Tongue
English
Weight
751 KB
Volume
6
Category
Article
ISSN
0884-0431

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Effect of the mi allele on mast cells, b
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The osteopetrotic, microphthalmic (mi/mi) mouse lacks functional osteoclasts and has also been reported to be deficient in mast cells and natural-killer (NK) cells. The later deficiencies could be secondary to the osteopetrotic marrow, or a direct result of the mi allele. Therefore, heterozygotes we