Coexistence of HER2 over-expression and p53 protein accumulation is a strong prognostic molecular marker in breast cancer
✍ Scribed by Hiroko Yamashita, Mariko Nishio, Tatsuya Toyama, Hiroshi Sugiura…
- Book ID
- 120701228
- Publisher
- BioMed Central
- Year
- 2003
- Tongue
- English
- Weight
- 190 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1465-5411
- DOI
- 10.1186/bcr738
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## Background: In view of the cumulative results to date, p53, nm23, erbb-2, and cathepsin d are the most promising investigational prognostic factors in breast cancer. ## Objectives: The clinical utility of these molecular markers to predict recurrence was evaluated. ## Methods: Archival patho
## Abstract The __FHIT__ tumor suppressor gene, which encompasses the fragile site __FRA3B__ at 3p14.2, is altered frequently in many types of human cancers. To determine its importance as a prognostic marker in breast cancer, the expression of the FHIT protein was studied in a series of 452 breast