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Coexistence of congenital afibrinogenemia and protein c deficiency in a patient

✍ Scribed by Masaharu Hanano; Dr. Hoyu Takahashi; Akira Shibata; Masakazu Itoh

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 303 KB
Volume: 41
Category: Article
ISSN: 0361-8609
DOI: 10.1002/ajh.2830410111

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✦ Synopsis

Abstract

A rare association of congenital afibrinogenemia and hereditary protein C deficiency is described in a 37‐year‐old female who suffered from ischemic necrosis in the left first toe. The diagnosis of afibrinogenemia was assessed by the absence of fibrinogen in clotting and immunological assays. The diagnosis of hereditary heterozygous type I protein C deficiency was based on the evidence of proportional decreases of activity and antigen of plasma protein C in the propositus, her mother, and two maternal aunts. © 1992 Wiley‐Liss, Inc.

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