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Codon usage is imposed by the gene location in the transcription unit

✍ Scribed by Marie-Odile Delorme; Alain Hénaut

Book ID
104720185
Publisher
Springer-Verlag
Year
1991
Tongue
English
Weight
564 KB
Volume
20
Category
Article
ISSN
0172-8083

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✦ Synopsis

A characteristic profile of the fluctuations of codon usage is observed in bacteriophages and mitochondria. By following the DNA in the direction of transcription, one moves slowly from a region where selective pressure favours codons ending with C to a region where the bias is in favour of codons ending with T; then, abruptly, one again enters a region of codons ending in C. The transcription end point takes place in the area of abrupt change in codon usage. By comparing Drosophila yakuba and mouse mitochondrial genomes, it is possible to show that the strategy of codon usage for a given gene depends on its location along the transcription unit and not on the encoded protein. The choice of codons ending in T or C allows large scale variations of DNA stability which could regulate the speed of propagation of the RNA polymerase.

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✍ Henri Wintz; Maureen R. Hanson 📂 Article 📅 1991 🏛 Springer-Verlag 🌐 English ⚖ 458 KB

Analysis of the cDNA of the atp9-1 gene transcript from petunia mitochondria has revealed that ten C residues of the gene sequence are edited into U in the mRNA. Seven of these edits result in amino acid changes and one introduces a stop codon before the end of the open reading frame predicted from