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Codon recognition: The allosteric ribosome hypothesis

โœ Scribed by Carl R. Woese

Publisher
Elsevier Science
Year
1970
Tongue
English
Weight
332 KB
Volume
26
Category
Article
ISSN
0022-5193

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โœฆ Synopsis

It is possible that simple base pairing between codon and anticodon triplets is incapable of providing the accuracy required for the translation process. An auxiliary mechanism for increasing this accuracy is herein proposed, whereby the ribosome recognizes the codon, in response to which it assumes a particular configuration. The ribosomal configuration in turn controls which of the tRNA species are permitted access to any given codon. Evidence supporting the model and some of its predictions are discussed.

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