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Codon 72 polymorphism of p53 and HPV type 16 E6 variants as risk factors for patients with squamous epithelial lesion of the uterine cervix

✍ Scribed by Burroni, E.; Bisanzi, S.; Sani, C.; Puliti, D.; Carozzi, F.

Book ID: 118763080
Publisher: John Wiley and Sons
Year: 2012
Tongue: English
Weight: 101 KB
Volume: 85
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.23417

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A polymorphism at codon 72 of the p53 gene, resulting in either an arginine or a proline residue in the protein, has been reported to affect the susceptibility of p53 to human papillomavirus (HPV) E6-mediated degradation in cultured cells. However, the relevance of this polymorphism to naturally occ