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Codominant translational mutants of Chinese hamster ovary cells selected with diphtheria toxin

โœ Scribed by T. J. Moehring; D. E. Danley; J. M. Moehring

Book ID
112558829
Publisher
Springer
Year
1979
Tongue
English
Weight
822 KB
Volume
5
Category
Article
ISSN
1572-9931

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Methotrexate (MTX) covalently linked to poly(L-lysine) [poly(Lys)] enters cells by endocytosis, is degraded in lysosomes and, upon liberation of small molecular methotrexate, is cytocidal to Chinese hamster cells in culture. This drug conjugate was used to select mutants resistant to MTX-poly(Lys),