Co–Cr–Mo alloy particles induce tumor necrosis factor alpha production in MLO-Y4 osteocytes: A role for osteocytes in particle-induced inflammation

Calcineurin/nuclear factor of activated

Calcineurin/nuclear factor of activated T cells (NFAT) signaling in cobalt–chromium–molybdenum (CoCrMo) particles-induced tumor necrosis factor-α (TNFα) secretion in MLO-Y4 osteocytes

✍ Vbenosawemwinghaye Orhue; Arihiko Kanaji; Marco S. Caicedo; Amarjit S. Virdi; Da 📂 Article 📅 2011 🏛 Elsevier Science 🌐 English ⚖ 239 KB

## Abstract Aseptic loosening is the devastating long term complication of total hip arthroplasty and orthopedic implant debris has been shown to trigger an intense inflammatory reaction leading to resorption of the bone matrix. Inflammatory cytokines, such as tumor necrosis factor‐α (TNFα), have b