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Cocoa Extracts Reduce Oligomerization of Amyloid-β: Implications for Cognitive Improvement in Alzheimer's Disease

✍ Scribed by Wang, Jun ;Varghese, Merina ;Ono, Kenjiro ;Yamada, Masahito ;Levine, Samara ;Tzavaras, Nikos ;Gong, Bing ;Hurst, William J. ;Blitzer, Robert D. ;Pasinetti, Giulio Maria

Book ID
125331127
Publisher
IOS Press
Year
2014
Tongue
English
Weight
417 KB
Volume
41
Category
Article
ISSN
1387-2877

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Three loci that modify β-amyloid (Aβ) accumulation and deposition in the brains of a mouse model of Alzheimer's disease have been previously described. One encompasses the Psen2 gene encoding presenilin 2, a component of the γ-secretase activity responsible for generating Aβ by proteolysis. We show