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Cochlear disorder associated with melanocyte anomaly in mice with a transgenic insertional mutation

✍ Scribed by Tachibana, Masayoshi


Book ID
123559071
Publisher
Elsevier Science
Year
1992
Weight
123 KB
Volume
17
Category
Article
ISSN
0921-8696

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A human COL2A1 gene with an Arg519Cys mu
✍ Janne Sahlman; Marja T. PitkΓ€nen; Darwin J. Prockop; Machiko Arita; Shi-Wu Li; H πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 471 KB πŸ‘ 1 views

## Abstract ## Objective An arginine‐to‐cysteine substitution at position 519 of the __COL2A1__ gene causes early generalized osteoarthritis with mild chondrodysplasia in humans. In this study, a human __COL2A1__ gene with the same mutation was introduced into a murine genome having 1 or no allele