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Cocaine self-administration alters the morphology of dendrites and dendritic spines in the nucleus accumbens and neocortex

✍ Scribed by Terry E. Robinson; Grazyna Gorny; Elizabeth Mitton; Bryan Kolb

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 219 KB
Volume: 39
Category: Article
ISSN: 0887-4476
DOI: 10.1002/1098-2396(20010301)39:3<257::aid-syn1007>3.0.co;2-1

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Rats were given repeated injections of 10 mg/kg of morphine and were then left undisturbed for 24-25 days before their brains were processed for Golgi-Cox staining. Prior exposure to morphine decreased the complexity of dendritic branching and the number of dendritic spines on medium spiny neurons i