Cocaine-induced changes in extracellular dopamine determined by microdialysis in awake squirrel monkeys
โ Scribed by P. W. Czoty; J.B. Justice Jr; L. L. Howell
- Book ID
- 105884061
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 115 KB
- Volume
- 148
- Category
- Article
- ISSN
- 0033-3158
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Fluoxetine (FLU) rapidly enhances extracellular (EC) serotonin (5-HT) in rodent brain, whereas the antidepressant effects of this drug in humans are typically not observed for 2-3 weeks. Thus, the effects of chronic oral FLU administration on neocortical and hippocampal EC 5-HT, and on caudate EC 5-
Cocaine-induced increases in extracellular dopamine (DA) concentrations were measured using in vivo microdialysis techniques in the nucleus accumbens (NACC) of freely moving rats. In control animals, cocaine increased extracellular DA concentrations approximately 482% 60 min following administration