𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Cocaine: Effects on acoustic startle and startle elicited electrically from the cochlear nucleus

✍ Scribed by T. Patrick Harty; Michael Davis

Publisher
Springer
Year
1985
Tongue
English
Weight
402 KB
Volume
87
Category
Article
ISSN
0033-3158

No coin nor oath required. For personal study only.

✦ Synopsis

Startle-like responses can be elicited by single pulse electrical stimulation of nuclei within the acoustic startle pathway. Compared with acoustically-elicited startle, this technique provides a method for localizing the ultimate sites of action of a drug that affects the acoustic startle response. Strychnine (1 mg/kg) increased both acoustically-elicited startle and startle elicited from the ventral cochlear nucleus (VCN), the first central nucleus in the acoustic startle pathway. In contrast, cocaine (10 mg/kg) increased acoustically-elicited startle but depressed VCN-elicited startle. These results suggest that cocaine increases startle by acting on sensory rather than final motor systems and are discussed in relation to the putative effect of cocaine on dopamine neurotransmission and the involvement of dopamine in sensorimotor reactivity.

πŸ“œ SIMILAR VOLUMES

The effects ofl-Dopa, clonidine, and apo
The effects ofl-Dopa, clonidine, and apomorphine on the acoustic startle reaction in rats
✍ Laurence D. Fechter πŸ“‚ Article πŸ“… 1974 πŸ› Springer 🌐 English βš– 782 KB

The present investigation provides evidence for noradrenergic involvement in the elaboration of the acoustic startle reaction. Within-subject experiments demonstrated that an amine-depleting dose of reserpine enhanced the level of the startle reaction and that this effect was reversed by the catech

A comparison of the effects of RO15,1788
A comparison of the effects of RO15,1788 and chlordiazepoxide on hot-plate latencies, acoustic startle, and locomotor activity
✍ Thomas J. Walsh; Ronnie L. McLamb; Hugh A. Tilson πŸ“‚ Article πŸ“… 1986 πŸ› Springer 🌐 English βš– 707 KB

RO15,1788, (a selective benzodiazepine antagonist) and chlordiazepoxide (an anxiolytic 1,4-benzodiazepine) produced time-dependent and dose-dependent effects on various indices of sensory-motor function. RO15,1788 increased hot-plate latencies at doses (10-60 mg/kg) that had no effect on locomotor a