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Cocaine doses equivalent to those abused by humans occupy most of the dopamine transporters

✍ Scribed by Nora D. Volkow; S. John Gatley; Joanna S. Fowler; Jean Logan; Marian Fischman; Andrew N. Gifford; Naome Pappas; Payton King; Stephen Vitkun; Yu-Shin Ding; Gene-Jack Wang

Book ID: 102656773
Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 1010 KB
Volume: 24
Category: Article
ISSN: 0887-4476
DOI: 10.1002/(sici)1098-2396(199612)24:4<399::aid-syn7>3.0.co;2-8

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✦ Synopsis

PET, [llC]d-threo-methylphenidate,

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GBR12909 (GBR) is a high-affinity, selective, and long-acting inhibitor of dopamine (DA) uptake that produces a persistent and noncompetitive blockade of DA transporters and substantially reduces cocaine-induced increases in extracellular DA in the nucleus accumbens of rats. Prior studies showed tha