Concentration and occupancy of dopamine
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Jean Logan; Nora D. Volkow; Joanna S. Fowler; Gene-Jack Wang; Marian W. Fischman
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Article
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1997
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John Wiley and Sons
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English
β 126 KB
The concentration (Bmax) of the dopamine transporter (DAT) and the maximum and effective occupancies by cocaine doses of 0.1 mg/kg or 0.05 mg/kg were measured in the striatum of cocaine abusers (n Ο 12) by using [ 11 C]cocaine as a radiotracer for the DAT and positron emission tomography (PET). Two