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Cocaine abusers do not show loss of dopamine transporters with age

✍ Scribed by Gene-Jack Wang; Nora D. Volkow; Joanna S. Fowler; Marian Fischman; Richard Foltin; Naji N. Abumrad; Jean Logan; Naomi R. Pappas


Book ID
117175191
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
571 KB
Volume
61
Category
Article
ISSN
0024-3205

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Concentration and occupancy of dopamine
✍ Jean Logan; Nora D. Volkow; Joanna S. Fowler; Gene-Jack Wang; Marian W. Fischman πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 126 KB

The concentration (Bmax) of the dopamine transporter (DAT) and the maximum and effective occupancies by cocaine doses of 0.1 mg/kg or 0.05 mg/kg were measured in the striatum of cocaine abusers (n Ο­ 12) by using [ 11 C]cocaine as a radiotracer for the DAT and positron emission tomography (PET). Two