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Cobalt(III) complexes of formyl- and acetylpyrazine N(4)-substituted thiosemicarbazones

✍ Scribed by Douglas X. West; Mark A. Lockwood; Alfonso Castineiras

Book ID: 110373195
Publisher: Springer
Year: 1997
Tongue: English
Weight: 446 KB
Volume: 22
Category: Article
ISSN: 0340-4285
DOI: 10.1023/a:1018598810355

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The purpose of this study was to evaluate the mechanism by which 2-acetylpyrazine-4 N-substituted thiosemicarbazone copper II complexes mediate their cytotoxicity. These compounds were shown to be cytotoxic to a variety of human and rodent tumors in cell culture and are potent cytocidal agents as de